The thermal loads on IGUs cause thermal stresses in glass elements and contribute to the climatic loads and consequent glass deflection. The influence of the variety of advanced coatings, different geometries and orientation of IGU on the thermal-mechanical behaviour of the glass elements at climatic loads still are not fully investigated. The aim of this investigation is to evaluate the mechanical behaviour of glass as a result of transient temperature fields in the gas space and glass elements of IGUs with different coatings, geometries and orientations. Mathematical models of transient conjugated heat transfer is composed, validated and applied for numerical calculations of the temperature fields in the glass elements and temperature, velocity and pressure fields in the gas space of insulating glass units by computational fluid dynamic technique.