To aid in solving problems associated with the parenteral product, the process used for manufacturing glass containers and some effects of factors in this process are discussed. Forming steps such as blowing, drawing, and flame working which affect the internal surface of the container are the most critical. They can result in an internal surface chemical resistance that is quite different from the outside or the bulk resistance. "Foreign" material can be introduced as contaminants in the atmosphere or as particulates. Reactions between the parenteral drug and the container or material extracted from the container are important. The glass producer and the parenteral packager must work closely together to solve the various problems that might arise.