Recent Developments In Type C Stationary Phases: Exploiting The Versatility Of Silica Hydride Materials

Type C silica is a relatively new chromatographic material that has been finding ever-increasing uses in the last few years. The properties exhibited by these stationary phases are often significantly different than the ordinary silica used for most commercial products. While all TYPE C phases can be utilised in the reversed-phase, organic normal phase and aqueous normal phase modes, there are some unique capabilities within each retention mode that have resulted in innovative method development strategies with great success. Some of the more challenging separation problems involve polar compounds; two approaches for the analysis of hydrophilic compounds are described in this report.