The use of high-power pulsed lasers to probe the response of materials at pressures of hundreds of GPa up to several TPa, time durations of nanoseconds, and strain rates is revealing novel mechanisms of plastic deformation, phase transformations, and even amorphization. This unique experimental tool, aided by advanced diagnostics, analysis and characterisation, allows us to explore these new regimes that simulate those encountered in the interiors of planets. Fundamental Materials Science questions such as dislocation velocity regimes, the transition between thermally-activated and phonon drag regimes, the slip-twinning transition, the ultimate tensile strength of metals, the dislocation mechanisms of void growth are being answered through this powerful tool.