General Understanding On Physical Stability Of Pharmaceutical Glasses

Although amorphous solid dispersion is one of the most important formulation technologies for poorly soluble drugs, the number of marketed oral amorphous formulations is still limited. The lack of an accelerated study protocol for predicting crystallization behavior of amorphous forms has been one of the biggest issues that inhibit their wide use. Isothermal crystallization behavior of pharmaceutical glasses is discussed in this presentation with an eventual aim of predicting physical stability of amorphous dosage forms.