Architectural designs of the last few years show for building skins in the field of commercial and office buildings a tendency for increasing transparency. One of the solutions approached in research is to use the glass panels not only as infilling elements, but also as structural elements. Hybrid steel-glass structures for building skins show a high complexity, due to the large number of factors which influence their design. Beside the structural behaviour, geometrical shapes, glass panel dimensions, actions and functional requirements have to be considered. In this paper an overview of these factors is given and issues to take into concern when designing hybrid steel-glass building skins and their connections are pointed out in an exemplary study for three different geometries.