This presentation is an overview of the findings from June 21-22, 2010, American Ceramic Society Leadership Summit, and a personal perspective on the economic issues and technical feasibility of achieving breakthrough technologies in the business segments of Energy and Healthcare. The top 10 rankings from an extensive listing of 100 potentially important ceramic, glass and glass-ceramic technologies were all in the Energy and Healthcare Sectors of business. Innovative technologies that have the potential for being world-changing are discussed, including Transforming Technology for Energy No 1: Innovative Energy Storage Devices; Transforming Technology for Healthcare No 1: Bioactive Materials for Regeneration of Tissues: No2: Localised Therapies for Cancer and Autoimmune Diseases; No 3: Tissue Engineering of Soft Tissues; No 4: Stem Cell Engineering; No 5: Preventative Medicine.