Experimental Evidence On The Characterisation Of Hydrolytic Extracts By Flame Photometry And Titration (In Italian)

The monograph "glass containers" of the European Pharmacopoeia is being revised presently with a view to a possible harmonization with relevant ISO standards. Among others, the opportunity is considered of introducing the determination of sodium in the hydrolytic extracts by flame photometry. When setting limit values it must be taken into account that for type I glass vials 1ml of 0.01 HCl titrates up to a maximum of 250ug Na20. To accomplish the stoichiometric equivalence (310ug Na20) a suitable fraction of migrated aluminium might be titrated as a soluble boron complex at pH 5.5.