Enhancing In Vitro Bioactivity Of Melt-Derived 45S5 Bioglass

45S5 Bioglass is a frequently applied Type A bioactive material, capable of forming an inherent bond to bone and soft tissue. Currently, applied melt-derived bioactive glass powders exhibit particle sizes between a few to several hundred micrometers. Recent studies on nanometer-sized bioactive glasses (nBGs), produced by bottom-up methods like sol-gel processing or flame spray pyrolysis, have indicated their great potential for several biomedical applications. In this study, the feasibility of top-down processing starting from bulk 45S5 BG by wet comminution in a stirred media mill was investigated.