The Istituto Superiore di Sanita promoted a study on lead availability from crystalware. The study was conducted in collaboration with a glass research institute, on glass articles provided by two major Italian lead crystal producers. The whole spectrum of lead-bearing glasses from 7 to 32% PbO was investigated. Short-term extraction tests carried out with 4% acetic acid on three sets of 24% PbO stemware of different composition, show that lead release is closely related to the hydrolytic resistance of the glass. A linear correlation was found between sodium released from the bulk glass and lead released from the surface at any time after the first leach. Experiments of repeated leaching with wine and brandy showed that lead release decreases with increasing number of extractions, similarly to the decrease observed with 4% acetic acid.