Cell Proliferation, Morphology & Differentiation Of Transgenic-Cloned Pig Calvarial Osteoblasts On The Silicon-Substituted Hydroxyapatite Ceramics Fabricated By Ultrasonic Spray-Pyrolysis Technique

Hydroxyapatite (HAp) is one of the most well known materials used as bone graft. Silicon (Si) ions were incorporated into the HAp lattice to increase the bioactivity of HAp, because Si appears to be beneficial to bone and connective tissue health. In this study, to investigate the influence of Si on proliferation, morphology and differentiation of calvarial osteoblasts derived from transgenic-cloned pg, silicon substituted hydroxyapatite ceramics were fabricated. As a result, a significant increment of cell proliferation and well stretching of actin bundles were observed on all samples.